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CBD Oil Drug Interactions – What you need to know

by My Natural CBD February 28, 2019

CBD interactions with the human body

Research has begun to demonstrate that cannabidiol (CBD) has the potential to effectively help a large number of people. CBD oil interacts with the endocannabinoid system in a way that produces very few unintended side-effects. While the majority of the vast majority of the science indicates CBD oil is safe for use and consumption, it may possibly pose a risk at reducing how well your level metabolizes other medicines. 

CBD Interaction

The Cytochrome P-450 System?

Found within the liver, the cytochrome P450 enzyme system is responsible for metabolizing potentially toxic compounds, including over 60% percent of any drugs you have consumed. According to Davis’s Drug Guide, this system contains more than 50 enzymes that process and eliminate toxins.

Why Does CYP450 Matter?

In order to determine the appropriate dosages of medications, doctors make calculations using the average amount of time it takes for various drugs and medications to be processed through the cytochrome P450 system. If only one drug is being processed, and the system is generally healthy, these averages provide accurate dosage information. However, certain substances have the ability to affect processing times within this system, making drugs metabolize faster or slower than they would on their own. These substances include grapefruit, watercress, St. John’s Wort, goldenseal and CBD.

CBD interactions

If you are taking a medication affected by cannabidiol, you should consult your doctor to make sure that it is safe for you to supplement your personal care routine with CBD oil. From there, the two of you may consider adjusting the dosage on your medications so that you can use both products safely.

Drugs that Interact with Cannabidiol

Any drug metabolized by CYP450 enzymes could potentially interact with cannabidiol. According to the Indiana University Department of Medicine, drugs known to use the CYP450 system include:

Steroids

HMG CoA reductase inhibitors

Calcium channel blockers

Antihistamines

Prokinetics

HIV antivirals

Immune modulators

Benzodiazepines

Antiarrythmics

Antibiotics

Anesthetics

Antipsychotics

Antidepressants

Anti-epileptics

Beta blockers

PPIs

NSAIDs

Angiotension II blockers

Oral hypoglycemic agents

Sulfonylureas

 

Medical Disclaimer

Always consult your physician before beginning any exercise program. This general information is not intended to diagnose any medical condition or to replace your healthcare professional. Consult with your healthcare professional to design an appropriate exercise prescription. If you experience any pain or difficulty with these exercises, stop and consult your healthcare provider.

My Natural CBD
My Natural CBD


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